Sunday, 17 November, 2019

Measles Wipes Your Immune System's Memory, Increasing Vulnerability To Other Dangerous Diseases

Measles Wipes Your Immune System's Memory, Increasing Vulnerability To Other Dangerous Diseases How measles infections can wipe away immunity to other diseases
Anna Jefferson | 08 November, 2019, 08:07

The study published online on Thursday in the journal Science showed that the measles virus cancels part of the immune system's memory in both humans and ferrets. Later, a measles epidemic struck, and researchers returned to collect another set of blood samples.

"The measles virus is resetting your immune clock to a naive state, and all of the protection you got by living through other viral and bacterial infections is reduced going forward", said senior researcher Stephen Elledge.

Two detailed studies of blood from unvaccinated Dutch children who contracted measles now reveal how such infections can also compromise the immune system for months or years afterward, causing the body to "forget" immunity it had developed to other pathogens in the past. And if these are the consequences of measles in a high-income nation where death from the virus is rare, it's even more important this research be conducted in places where the disease is commonplace, he says.

The research begins to explain something surprising that happened when the measles vaccine was introduced in the U.S.in the 1960s. The vaccine's emergence cut measles cases by 80% between 2000 and 2017 and is credited with saving 21.1 million lives. "So to me this is a direct refutation of people who use the "natural infection is better" argument about why they don't want to vaccinate".

Each time you get a cold or an infection, your body forms antibodies to fight these bugs. However, after a few weeks, the patient's white blood cell count goes back up to previous levels and they have recovered from the measles, yet they are still much more susceptible to other infectious diseases.

The research finds that measles, which kills more than 100,000 children a year around the globe, is an even more risky germ than previously thought. The researchers sequenced the genes of immune memory cells and found that after recovering from measles, the children's immune system had a different landscape of certain types of cells.

The "Mina" study of 77 children, found that unvaccinated children who had measles lost between 11 and 73 per cent of their antibody repertoire two months after infection. "Babies are more vulnerable to infections because their immune system is still maturing".

Bill Gates isn’t sure how ‘open-minded’ Elizabeth Warren is
They said in a letter: "The United States has moral, moral and economic responsibilities, and taxes our wealth more. Warren responded on Twitter that she'd be more than willing to talk with Gates about her wealth tax.

People just acquired messages initially sent on Valentine's Working day
So at two: 30am, my cell phone made the choice to ship out a textual content material to my ex-girlfriend....from 9 months again. Gergs also said Valentine's Day messages were likely affected because the amount of texts sent on that day is "abnormally high".

Michael Bloomberg Filing to Run for President
That's what I'll do, including the launch of a new effort called Beyond Carbon", the billionaire said at the time . With more moderate views, Bloomberg could draw voters away from former Vice President Joe Biden.

"Every time we see a pathogen, our immune system recognizes this pathogen, builds immunity to it and then stores it in the form of immune memory", explains Velislava Petrova, a postdoctoral fellow in immunogenetics at the Wellcome Sanger Institute in the United Kingdom and first author of the report published in Science Immunology. In other words, while measles survivors struggle to defend themselves against other pathogens, their bodies can fend off a repeat attack by the measles virus itself.

Measles is a risky virus, and before the introduction of the vaccine, it infected 3 to 4 million children, killing between 400 and 500 annually in the United States.

The research from the Wellcome Sanger Institute, University of Amsterdam checked out 26 unvaccinated kids sooner than and after catching measles.

The researchers confirmed that finding by infecting flu-vaccinated ferrets with a measles-like illness. "Measles is not as harmless of a disease as many people think". Basically, the measles virus doesn't just delete immune memory-it makes it harder for the immune system to respond to new pathogens in the future.

"You have this really rapid [antibody] decline with measles, and then a slow increase", he said.

Families in communities with low vaccination rates agreed to provide blood samples, allowing researchers to observe the effects of a measles infection on non-vaccinated people. In some children the effect is so strong it is similar to being given powerful immunosuppressive drugs. As a result, some Americans still view measles as relatively harmless-which, in addition to a unsafe uprising of anti-vaccine sentiment, has led some parents to decline shots for their children, contributing to a resurgence of preventable illness in the USA and overseas. Not only could they contract measles and suffer directly from the virus but could also sustain measles-included damages to their immunity. This new research clearly points out that your immune system is debilitated by measles and implies that the measles vaccine is precious than previously recognized. These findings further strengthen the vital role the MMR vaccine plays in public health and protecting us from deadly disease. "It is yet another reminder of how important vaccines are as a vital resource in eliminating infectious disease".

This article has been republished from the following materials.

Recommended

Load management is spoiling a potential NBA Finals preview Load management is spoiling a potential NBA Finals preview Leonard returned to play October 31, in a victory against San Antonio, just as he is expected to play Thursday against Portland. When fans pay to watch the Los Angeles Clippers , for example, they are likely hoping to see Kawhi Leonard on the floor.

Many missing after deadly ambush near Canadian-run mine in Burkina Faso Many missing after deadly ambush near Canadian-run mine in Burkina Faso Then in August 2017, 18 people were killed in an attack on a Turkish restaurant in the capital. There is no danger to the mine itself at the moment, the company has said meanwhile.

Former U.S. attorney-general Jeff Sessions enters Senate race in Alabama Former U.S. attorney-general Jeff Sessions enters Senate race in Alabama And I'll tell you why. "Alabama deserves a senator who will stand with the president and won't run away and hide from the fight". Sessions' entry into the race would put Trump in a position of having to endorse him or some other Republican.

All 39 Essex lorry victims have been formally identified, police say All 39 Essex lorry victims have been formally identified, police say Essex Police said a series of files had been brought before an identification commission with the assistance of Vietnamese police. He said the Vietnamese government strongly condemns human trafficking activities and the illegal transport of people overseas .

Cris Carter, Fox Sports part ways after reported disagreement about his role Cris Carter, Fox Sports part ways after reported disagreement about his role The post Cris Carter out at Fox Sports appeared first on Awful Announcing . It's unclear what this means for FOX's First Things First moving forward.

Elderly Man Found Dead After Falling Into Underground Lava Tube In Hawaii Elderly Man Found Dead After Falling Into Underground Lava Tube In Hawaii An autopsy conducted on Tuesday determined that the man died as a result of 'injuries consistent with falling'. The fire department was called in for a rescue, but he was pronounced dead at a nearby medical center.

Jury selection to resume Wednesday in trial of Trump adviser Stone Jury selection to resume Wednesday in trial of Trump adviser Stone Stone was in contact with WikiLeaks founder Julian Assange , who was confined to the Ecuadorian Embassy in London at the time. Stone, 67, is accused of lying to Congress and pressuring another person to do the same.

Libra Won’t Spread as Quickly as Facebook, Says Calibra Exec Libra Won’t Spread as Quickly as Facebook, Says Calibra Exec Its panel of backers should govern libra, and wherein Facebook will play a part as a member. The OAIC is the national regulator for privacy and freedom of information.

Amazon Has Another Sale Starting Tomorrow, But Deals are Already Live Amazon Has Another Sale Starting Tomorrow, But Deals are Already Live In the meantime, these are a few of the best deals we've spotted in Target's Black Friday ad. To stay in-the-know for all the best savings, check the website or download the Target app .

UEFA Champions League Report: Liverpool v Genk 05 November 2019 UEFA Champions League Report: Liverpool v Genk 05 November 2019 Salah has been directly involved in 68 goals in 59 appearances for Liverpool at Anfield across all competitions (50 goals and 18 assists).

Stoke City Make Approach For Northern Ireland Manager Michael O’Neill Stoke City Make Approach For Northern Ireland Manager Michael O’Neill The manager guided Northern Ireland to the European Championships in 2016, where they were eventually beaten in the last 16. O'Neill will take over with Stoke bottom-of-the-table but with a hugely talented squad and money to spend in January.

Apple TV 4K is on sale for an all-time low of $90 Apple TV 4K is on sale for an all-time low of $90 The condition to avail this offer is that device should have been bought after September 10, 2019 to be eligible for the offer. Apple has officially introduced its ad-free Apple TV + subscription service, priced at United States dollars 4.99 per month.

Judge orders Trump to pay $2M to settle charity lawsuit Judge orders Trump to pay $2M to settle charity lawsuit The order for Trump to pay comes follows extensive reporting in The Washington Post about alleged wrongdoing at the foundation. Trump in the amount of $2,000,000, without interest, rather than the entire $2,823,000 sought by the Attorney General".

Bank set to slash growth outlook as rates remain unchanged Bank set to slash growth outlook as rates remain unchanged But economists at HSBC said a rate cut was not a certainty, as some policymakers looked concerned about rising labour costs. BOE is expected to hold current monetary policy unchanged with the downbeat quarterly outlook for growth and inflation.

Bańka to urge sponsors to back WADA in anti-doping battle Bańka to urge sponsors to back WADA in anti-doping battle "It was surprising", Tygart told Reuters on the sidelines of a world conference on doping in sport organised by WADA. He'll be under the microscope, as WADA deals with a continuing case involving Russian cheating.