Saturday, 24 August, 2019

Researchers eliminate HIV from DNA of infected mice for the first time

Ученые удалили все следы ВИЧ из тела очеловеченных мышей HIV BREAKTHROUGH - The Aids causing virus has been wiped out for first time in living animals
Anna Jefferson | 03 July, 2019, 21:44

In a study published Tuesday in Nature Communications, researchers from Temple University's Lewis Katz School of Medicine and the University of Nebraska Medical Center (UNMC) coupled genome editing technology with a slow-release virus suppression drug to eliminate HIV cells entirely from some infected mice. Current HIV treatment involves daily, lifelong antiretroviral therapy (ART) which suppresses the virus' ability to replicate, but doesn't eliminate the virus from the body.

That's not a huge number, and there are clear steps still to be taken before this can become a human clinical trial, but it's certainly a positive start.

The two labs initially began their research separately: Howard Gendelman at UNMC pursued trials with LASER ART, while Khalili at Temple University had been tampering with CRISPR technology for five years.

'We now have a clear path to move ahead to trials in non-human primates and possibly clinical trials in human patients within the year'.

However, in the last third, where researchers applied the two-step approach, they discovered that the mice genome had wholly got rid of HIV. The modified drug was packaged into nanocrystals, which readily distribute to tissues where HIV is likely to be lying dormant.

To test their idea, the researchers used mice engineered to produce human T cells susceptible to HIV infection, permitting long-term viral infection and ART-induced latency. It's stored within these cells for weeks at a time, with antiretroviral drugs slowly released. First matter "drives the virus to a standstill", and then editing system genes "finishes" of HIV. CRISPR-Cas9 is found effective with fewer cells, which the LASER ART did great.

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Researchers say they found a possible cure for HIV in a new breakthrough study that successfully eliminated the virus from the DNA of mice.

Excision BioTherapeutics Inc.is a life science company focused on the development and commercialization of advanced gene editing therapeutics for the treatment and eradication of life-threatening disease caused by neurotropic viruses (viral infections). Jonathan Stoye, a virologist at the Francis Crick Institute in London, who was not involved with the study, wants to know why the treatment didn't work in more of the mice, for example.

Dr. Khalili's team used CRISPR-Cas9 technology to develop a novel gene editing and gene therapy delivery system aimed at removing HIV DNA from genomes harboring the virus.

He added: "Only by pooling our resources together were we able to make this groundbreaking discovery".

In a nutshell, the first treatment suppresses HIV over a long period of time, and the second one cuts out large chunks of HIV DNA from infected cells.

What we really need is a therapy that completely eliminates HIV from the body, which is precisely what Khalili and his colleagues have been working on for the past several years. The researchers now believed they have solved the problem.

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