Saturday, 17 August, 2019

New HPV vaccine recommendation for people through age 45

CDC panel recommends HPV vaccine for men through age 26 and for some older adults Rich nations could end cervical cancer within decades, say experts
Anna Jefferson | 27 June, 2019, 18:52

Elimination of cervical cancer in wealthy countries such as the United Kingdom may be possible within decades, say experts, following a major study showing the success of the HPV jab in protecting women.

Not only was the HPV virus affected, but anogenital wart diagnoses decreased significantly by 67% among girls aged 15 to 19 years, decreased by 54% among women aged 20 to 24 years, and decreased significantly by 31% among women aged 25 to 29 years.

The study also noted a dramatic decrease in cases of precancerous cervical lesions among screened teenage girls and young women, and anogenital warts across all age groups of women and men.

"We will see reductions in women aged 20-30 within the next 10 years", he added.

He said cervical cancer elimination - defined as fewer than four cases per 100,000 - "might be possible if sufficiently high vaccination coverage can be achieved and maintained".

Cervical cancer could one day be eradicated thanks to the success of widespread human papilloma virus (HPV) vaccination programmes, scientists have claimed.

The researchers, led by Laval University in Canada, said that if the number of people having the vaccination remains high, the cancer could soon be eliminated.

Currently, the NHS offers the first dose of the HPV vaccine to girls aged 12 and 13, with the second dose being given six to 12 months later. We don't have a precise date but we're trying to determine when it will occur'.

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Eligible studies compared the frequency of at least one HPV-related endpoint (genital HPV infections, anogenital wart diagnoses, or histologically confirmed cervical intraepithelial neoplasia grade 2+ [CIN2+]) between pre- and post-vaccination periods among the general population and used the same population sources and recruitment methods before and after vaccination.

Several countries also have pilot programs and/or are in the process of introducing HPV vaccination.

From September, the United Kingdom will begin offering HPV vaccination to boys, which will further reduce the pool of the virus. The rates also fall in those regions were people belonging to wider age groups were vaccinated.

"We sincerely hope this will boost public faith in the HPV vaccine, so that more lives can be saved and we get closer to a world where cervical cancer is a thing of the past", Robert Music, chief executive of Jo's Cervical Cancer Trust, said. Previously, men were recommended to get the vaccine up until age 21. At the moment, the burden of cervical cancer is in women who were too old to be vaccinated - the vaccine is not very effective in women who are sexually active and may have already been exposed to the virus. These results are showing that the HPV infection rates are lowering after the vaccination program started.

There are 3,200 cases of cervical cancer and 850 deaths from the disease each year.

The higher the CIN grade, the higher the risk of developing invasive cancer.

In a 10-4 vote, the committee also recommended adults ages 27 through 45 who had not been adequately vaccinated make shared decisions with their doctors about getting vaccinated.

He added: "We're lucky to have the HPV vaccination programme here in the United Kingdom, and this study supports the imminent rollout of the gender-neutral HPV vaccine".

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