Wednesday, 20 March, 2019

FDA Shows Green Signal for Johnson & Johnson's Fast-Acting Depression Drug

J&J nasal spray gets U.S. approval as first new type of anti-depressant in decades FDA approves new treatment for depression in the form of nasal spray
Anna Jefferson | 09 March, 2019, 04:22

The approval comes after an FDA advisory panel in February voted heavily in favor of the drug esketamine, saying its benefits outweighed the risks. He also is named as co-inventor on patents filed by the Icahn School of Medicine relating to the treatment for treatment-resistant depression, suicidal ideation and other disorders.

Esketamine is a departure from Prozac-era of antidepressants.

The U.S. Food and Drug Administration on Tuesday said it approved a Johnson & Johnson nasal spray antidepressant for people resistant to other treatments but placed restrictions on use of the drug, which it warned could be misused and abused.

Courtney Billington, the President of Johnson & Johnson's Janssen neuroscience division said that they have worked relentlessly to ensure that they have available resources with them to help patients with severe depression and the patients who were awaiting a quicker solution to get relief.

Spravato is a form of ketamine, originally approved in the 1970s and used as an anesthetic. The drug can not be taken home for unsupervised use. Given in low doses through infusions, he says Ketamine is safe and effective.

Nevertheless, many hope that this new treatment will be a step in the right direction for mental health in the United States. He said the approval legitimizes the approach he and other doctors have been taking.

The FDA says the most common side effects of the drug observed in the trials included disassociation, dizziness, nausea, sedation, vertigo, decreased feeling or sensitivity (hypoesthesia), anxiety, lethargy, increased blood pressure, vomiting and feeling drunk.

North Korea rapidly rebuilds rocket launch site
United States political strategist Evan Siegfried questioned whether it was triggered by weapon testing in North Korea. The development came after a high-stakes nuclear summit last week between North Korean leader Kim Jong Un and U.S.

‘Wenger would never lose this match’ - Arsenal fans turn on Unai Emery
Hatem Ben Arfa says he couldn't help but laugh at Unai Emery during Arsenal's defeat to Stade Rennais. But Emery will be hoping that they wrap up the tie in the first leg itself.

Huawei P30 Pro to Sport Periscope-Style Zoom Camera, VP Confirms
Such a photograph suggests the P30 Pro will present a huge upgrade from the 3-times optical zoom offered by its predecessor. So it seems we can expect the P30 Pro to feature a zoom mechanism quite unlike the fixed lens setup of the P20 and Mate 20.

"The approval of esketamine is a groundbreaking advance in the treatment of depression, given its novel mechanism of action and time frame at which it produces clinically meaningful improvements", he told MedPage Today.

Unlike ketamine, psilocybin and MDMA have no legal medical use.

Now available anti-depressants such as Eli Lilly and Co's Prozac work on neurotransmitters like serotonin and norepinephrine, but most drugs take at least four weeks to show effect and fail to produce an adequate response in about 30 percent to 40 percent of patients with major depressive disorder (MDD).

Spravato was developed by a group of researchers who discovered that ketamine has a rapid antidepressant effect. It did not, however, reveal the drug's list price. Out-of-pocket costs vary based on an individual's healthcare plans and the duration of treatment.

Spravato, which is administered via a nasal spray, is the first FDA-approved antidepressant in over 30 years.

But he hopes that doctors who are now using ketamine continue to do so.

Johnson & Johnson said the wholesale cost of each treatment with ketamine will range from $590 to $885, depending on the dose.

Recommended

Trans Mountain pipeline court decision weighed on SNC strategy: Butts Trans Mountain pipeline court decision weighed on SNC strategy: Butts Butts said all they wanted was for Wilson-Raybould to seek an outside legal opinion on the matter from an eminent retired judge. That's news to some of his cabinet ministers. "That is not what I said", Butts responded, when asked about the allegation.

Giants trade Olivier Vernon for Kevin Zeitler: How it impacts the cap Giants trade Olivier Vernon for Kevin Zeitler: How it impacts the cap He now projects as the starting outside edge rusher opposite Myles Garrett , offering a lither option than Emmanuel Ogbah . The Cleveland Browns made a trade with the New York Giants , but not the deal you're thinking of, for Odell Beckham .

DEVELOPING: Pats working on trade for DE Bennett DEVELOPING: Pats working on trade for DE Bennett Well, that certainly won't help the Eagles trade Bennett. "Of course you always want to be with the team that you play with". He is scheduled to earn a base salary of $6.2 million in 2019 with a $1 million roster bonus.

Samsung has another two foldables in the works Samsung has another two foldables in the works Galaxy Fold, a smartphone phone with a flexible screen (Dh7,250), will go on sale in the region in the second quarter of 2019. It may feature a second external display , like the Galaxy Fold, depending on how customers respond to the Fold.

Wallpapers hiding Samsung Galaxy S10’s cutout are my favourite thing online Wallpapers hiding Samsung Galaxy S10’s cutout are my favourite thing online Also, select Samsung Galaxy devices including the new S10 in the USA will come with six months of free Spotify Premium. These are the company's first batch of flagship phones with a "hole-punch" in their screen rather than a notch.

Houstonians with ties to Michael Jackson, Wade Robson react to 'Leaving Neverland' Houstonians with ties to Michael Jackson, Wade Robson react to 'Leaving Neverland' In a 1991 episode of " The Simpsons ", Michael Jackson voiced a character in a mental hospital who thought he was a pop star. He and Bart later write a song for his sister Lisa's birthday. "This was a treasured episode", Brooks continued.

Shamima Begum's Newborn Son May Have Died, Her Lawyer Claims Shamima Begum's Newborn Son May Have Died, Her Lawyer Claims The heavily pregnant Begum was found by a journalist from The Times when he visited the Al-Hol camp in February. ISIS bride Begum gave birth to two other children after she was captured, but both are believed to have died.

Trump partied with founder of massage parlor where Robert Kraft was busted Trump partied with founder of massage parlor where Robert Kraft was busted A screenshot taken from Cindy Yang's Facebook page showing her posing alongside Eric Trump. It does seem, however, to be a small world among the Palm Beach glitterati.

Daylight Saving Bill Moves Forward- Remember to Spring Forward Saturday Night Daylight Saving Bill Moves Forward- Remember to Spring Forward Saturday Night If the proposal becomes law, the time shift would be permanent, with more light at the end of the day and less in the morning. The first community in Canada to adopt Daylight Saving is Thunder Bay, Ontario, who turned their clocks forward back in 1908.

Marvel are casting first openly gay superhero Marvel are casting first openly gay superhero The studio is said to be open to actors of all ethnicity, but would prefer the role to go to an openly gay actor. "Our determination is to have that for all of the people out there watching our movies ".

Democrats bar Fox News from moderating debates after reported Trump ties Democrats bar Fox News from moderating debates after reported Trump ties According to DNC Chairman Tom Perez , Fox News is unable to host a "fair and neutral debate " for the Democratic candidates. PHOTO:Hillary Clinton speaks at the Democratic Presidential debate from St.

SpaceX crew capsule splashes down in Atlantic SpaceX crew capsule splashes down in Atlantic About 300 pounds of cargo, including unneeded hardware and scientific samples, were packed aboard the Dragon for the return trip. Success will also mean that "Earthy", a plush anthropomorphic doll of our planet, will be coming home from the space station.

Tesla is going to unveil their Y Model on 14th of March Tesla is going to unveil their Y Model on 14th of March Tesla said it had "already reached a resolution with Chinese customs". Anderson isn't advocating for Musk's ouster. Securities and Exchange Commission.

Ramos Shouts "Pay Me And I'll Leave" To Real Madrid President Ramos Shouts Coach Erik ten Hag said the performance had been "as close to perfection as you can get" and that his young Ajax side deserved to progress.

Antonio Brown calls impending trade-to-Bills report 'fake news' Antonio Brown calls impending trade-to-Bills report 'fake news' For what it's worth, NFL Network is the only outlet to have reported the deal and it has not been made official by either team. The Steelers were reportedly seeking top offers from clubs with an intent to reach a deal by Friday.