Tuesday, 22 January, 2019

1st baby born using uterus transplanted from deceased donor

Doctors hold a baby girl born to a mother who received a uterus from a deceased donor in Brazil. A novel transplantation procedure may help more infertile women become pregnant First baby born via uterus transplanted from dead donor
Anna Jefferson | 06 December, 2018, 13:51

The medical team at the Hospital das Clinicas holding the first baby to be born following a uterus transplant from a deceased donor.

The baby was delivered by way of a cesarean section on December 15, 2017 at around 36 weeks into the pregnancy. The woman's previously fertilised and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.

"When a transplant is dome from a live donor, there is a greater responsibility towards both the donor and recipient, but in a dead body the doctors can be a bit relaxed", Ms Sharma said. The donor uterus was removed from the receiving patient during the c-section.

Brazilian doctors said the first baby has been born to a woman with a uterus that was transplanted from a deceased donor, reports say.

The first successful childbirth following uterine transplant from a living donor took place in 2014 in Sweden, and there have been 10 others since then.

The uterus transplant, in this case, happened in September 2016.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.

"The successful case in our service brings hope to other centers that believe in this type of transplant", Ejzenberg said in an email to TIME. The donor was 45-years-old and had borne three children in her lifetime before dying of a stroke. During the transplantation, there was a period of blood loss that was ultimately managed but might be avoidable in the future, by changing how the organ is initially reconnected to the woman's circulatory system, according to the study.

"I'd have to say it's in the pipelines but there are easier ways to have children like finding a surrogate or adopting", she said.

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The current need for live donors "is a major limitation as donors are rare, typically being willing and eligible family members or close friends", Dr Ejzenberg said.

In a transplant surgery that lasted more than ten hours, doctors had to connect the donor's uterus with the veins, arteries, ligaments, and vaginal canal of the recipient.

Five months after the surgery, the medical team observed no signs of rejection, noting that ultrasound scans were normal and the recipient experienced regular menstruation. According to the authors of the case study, around one in 500 women have infertility associated with the womb.

Uterine transplants aren't about to become standard just yet.

"It enables use of a much wider potential donor population, applies lower costs and avoids live donors' surgical risks", Saso stated.

In the USA, around 10 percent of women aged between 15 to 44 struggle with fertility, according to the Centers for Disease Control and Prevention.

"They should promote education and guidance so that the groups performing uterus transplantation for the first time can benefit from the experience of the pioneers".

Infertility affects one in seven people in Britain, and while some problems can be solved through IVF, most women with womb issues have no alternative but adoption or surrogacy.

In the end, they held off an additional month after tests suggested the lining of the donor uterus wasn't quite thick enough to support implantation.

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