Wednesday, 26 September, 2018

Painkiller diclofenac linked to increased heart risks in study

Diclofenac could increase heart failure Diclofenac could increase heart failure
Anna Jefferson | 09 September, 2018, 04:59

Researchers discovered within the first 30 days of taking the common painkiller, some patients experienced several cardiovascular events such as a flutter, heart failure, heart attack, or ischemic stroke. But given the cardiovascular and gastrointestinal risks, there is little justification for starting a diclofenac treatment before testing other traditional NSAIDs, "the researchers concluded".

Now a groundbreaking study of more than six million people, the biggest of its kind, has linked them to "major cardiovascular events". Diclofenac is a traditional NSAID that has similar selectivity for cyclo-oxygenase-2 (COX 2) as COX 2 inhibitors, but the cardiovascular risks of diclofenac in comparison with other traditional NSAIDs have not been investigated through a randomized controlled trial.

Diclofenac is a NSAID used for treatment of pain and inflammation with the brand names Voltaren, Cataflam and Zipsor.

Using national population and prescription drug registries, they were able to look at the medical records of over 6 million Danish adults from 1996 to 2016.

Diclofenac is a component which is frequently found in painkillers which are usually used to alleviate back pain, arthritis, and sciatica.

More clear warnings should be given about the risks of diclofenac, say researchers who found a higher risk of heart attack and stroke associated with its use. Diclofenac should not be available over the counter, and when prescribed, should be accompanied by an appropriate front package warning about its potential risks'.

The risk of gastrointestinal bleeding at 30 days increased 4.5-fold in patients who started diclofenac compared to those who didn't.

Burberry to stop burning unsold items after green criticism
Models wear the the Spring/Summer 2018 collection for Burberry on the second day of The London Fashion Week , September 16, 2017. One of his first moves was to appoint Tisci, who Gobbetti worked with at Givenchy, as Burberry's chief creative officer.

Djokovic tops Federer’s conqueror for 11th U.S. Open semi in row
American player Nicole Gibbs told CNN a year ago that she'd first started receiving online abuse while playing college tennis . It was another hot afternoon Wednesday, with temperatures in the 30s C, but feeling much hotter due to the humidity.

Here's what David Epstein is saying about Hurricane Florence
East Coast this weekend as the storm swirls across the Atlantic, according to forecasters at the National Hurricane Center . The current projected path by the National Hurricane Center for the next few days can be viewed in the second image above.

The authors point out that, although the relative risk was increased, the absolute risk remained low for the individual patient.

Now, a team from Denmark has uncovered evidence that people who use diclofenac, one of the most commonly used NSAIDs and one often available without a prescription, experience significantly more serious adverse events than those taking other NSAIDs or paracetamol (aka acetaminophen).

The researchers said that despite the potential side effects, treatment with NSAIDs may be worthwhile for improving the quality of life of patients suffering from pain and inflammation.

However, they add: "This is an observational study, so no firm conclusions can be drawn about cause and effect".

People who have suffered heart failure, heart disease or a stroke should stop using it completely.

"It's time to acknowledge the potential health risk of diclofenac and to reduce its use", write Morten Schmidt, M.D., Ph.D., registrar, Henrik Toft Sørensen, M.D., Ph.D., clinical professor and chair, and Lars Pedersen, Ph.D., professor, department of clinical epidemiology, Aarhus University.

Recommended

Keys locks another U.S. Open semi-final Keys locks another U.S. Open semi-final That said, in Keys Osaka faces one of the few players capable of matching her blow for blow and not missing. She then dropped the first set to Serbia's Aleksandra Krunic but battled back to claim a 4-6 6-1 6-2 win.

Hundreds arrested in multi-day protests of U.S. Supreme Court nominee Hundreds arrested in multi-day protests of U.S. Supreme Court nominee Planned Parenthood, in a press release, also left out the words "they said" and later acknowledged the error, according to CNN . Kavanaugh faced numerous questions regarding his views on executive power and whether the president can pardon himself.

Spider-Man PS4 'Be Greater' launch trailer Spider-Man PS4 'Be Greater' launch trailer However, her role in Spider-Man is smaller than you may expect... at least for now. Did you manage to pick up a copy of Marvel's Spider-Man PS4?

Leroy Sane leaves German squad over 'private reasons' Leroy Sane leaves German squad over 'private reasons' Eyebrows were raised when Sane left Germany's team hotel after their 0-0 draw with world champions France on Thursday but there is no tension between the winger and Low.

Celtic's Jabari Bird Arrested For Assaulting, Choking & Kidnapping Somebody Celtic's Jabari Bird Arrested For Assaulting, Choking & Kidnapping Somebody Jabari Bird was arrested on Friday night on multiple charges including kidnapping, strangling and assault. He appeared in 13 regular-season games for the Celtics last season, averaging 3.0 points per game.

Idlib’s fate in balance as leaders meet Idlib’s fate in balance as leaders meet Trump will chair a UN Security Council meeting on Iran during an annual gathering of world leaders in NY later this month. Russian Federation has suggested the rebels could use chemical weapons in a final battle for the rebel stronghold.

BMW introducing voice-activated digital assistant BMW introducing voice-activated digital assistant It will land in the U.S., Germany, UK, France, Spain, Switzerland, Austria, Brazil, Japan at that time and hit China in May 2019. It's not clear if this means drivers would be able to say "Hey Bob" instead of "Hey BMW ".

BTS drop the official MV for 'IDOL' feat. Nicki Minaj BTS drop the official MV for 'IDOL' feat. Nicki Minaj The video for the new version of the song shows Minaj rapping while her lyrics appear on the background in Hangeul, the Korean alphabet.

Shooting under investigation in downtown Cincinnati Shooting under investigation in downtown Cincinnati She was on a conference call when she walked into lobby's revolving doors as the shooting began, the bank said in a statement. He says an investigator told him the suspect had enough ammunition to cause "a bloodbath beyond imagination".

Ford recalls 2 million F-150 trucks due to seat belt fires Ford recalls 2 million F-150 trucks due to seat belt fires The company says it has 23 reports of smoke or fire in the USA and Canada , but it's not aware of any injuries. When the pretensioner activates, it exhausts gases inside of the B-pillar, and sparks can ignite these gases.

Naomi Osaka pays tribute to 'idol' Serena as US Open showdown looms Naomi Osaka pays tribute to 'idol' Serena as US Open showdown looms She also added Conchita Martinez, the 1994 Wimbledon champion who guided Garbine Muguruza to Wimbledon glory previous year . The win sets up a tantalizing final between Williams and Osaka , 20, who considers Williams her idol .

Everybody move up: Tesla shuffles executive ranks Everybody move up: Tesla shuffles executive ranks Tesla shares fell as much as 10 percent to $252.25 in morning trading in NY , the steepest intraday drop since June 2016. Musk criticized the use of the drug while denying it had anything to do with attempting to take Tesla private .

Watt feeling confident ahead of return Sunday vs. Pats Watt feeling confident ahead of return Sunday vs. Pats I think that it will be close but the New England Patriots offense will come out on top. It's f-king going to be hard to do. "I'm really excited", he said.

India's top court decriminalizes homosexual acts India's top court decriminalizes homosexual acts Under Section 377 , the penalty was a 10-year jail term, although it has " hardly ever been used in cases of consenting adults ". In a concurring judgement, Justice Nariman said homosexuality is "not a mental disorder or disease".

A billion adults at risk from lack of exercise A billion adults at risk from lack of exercise The study was only based on activity levels that were self-reported by 1.9 million men and women from 358 population surveys. According to experts the levels of inactivity worldwide is alarming and not effort have been made to eradicate the scenario.