Saturday, 17 November, 2018

Scientists cautiously optimistic about HIV vaccine candidate

World AIDS day 2 Are we on the road to an HIV vaccine?Hide Caption
Anna Jefferson | 09 July, 2018, 21:56

Dr. Dan H. Barouch, a lead researcher on the study and a professor at Harvard Medical School, said he was "pleased" with the results but that they should still be treated with caution.

Researchers have made an important breakthrough in work to develop a vaccine to protect against HIV.

The mosaic vaccine HIV-1 vaccine produced comparable immune responses in both humans and rhesus monkeys, a phase I/IIa trial found.

An experimental HIV vaccine showed promise of protecting healthy adults from contracting the deadly virus that killed millions of people in the past years.

"Based on these data, the mosaic Ad26/Env HIV-1 vaccine has been advanced into a phase 2b clinical efficacy study to determine whether this vaccine will prevent HIV infection in humans in southern Africa", said Barouch.

Now published its key data on early stages, explained in the company Johnson & Johnson, whose daughter Janssen pharmaceuticals has developed a vaccine.

Meant to provide broad protection from the many strains of HIV that are prevalent worldwide, the "mosaic" vaccine contains a patchwork of genetic sequences found among various HIV strains. While the monkey test is encouraging, there need to be more tests to show that the drug could effectively fend off infections in humans.

Amazon Offers Free Echo Dot Ahead Of Prime Day
After that period expires, Amazon Prime costs about $12.99 (£9.79) per month. Shoppers can look for the deals on Amazon.com, the Amazon app and Alexa.

Starbucks Will Eliminate Plastic Straws Globally by 2020
The announcement comes after Seattle, Starbucks' home market, banned restaurants from using plastic straws and utensils on July 1. Last month, McDonald's announced that it would start testing plastic-straw alternatives at certain US locations later this year.

Starbucks to eliminate plastic straws by 2020
A number of restaurants and private establishments also have taken measures to curb their use of plastic straws. Frappuccino drinks will still be served with dome lids, but with straws made from paper or compostable plastic.

"The challenges in the development of an HIV vaccine are unprecedented, and the ability to induce HIV-specific immune responses does not necessarily indicate that a vaccine will protect humans from HIV infection", he added.

For now, people infected with HIV rely on lifelong virus-suppressing anti-retroviral treatment (ART) to stay healthy. Thousands of people are still contracting HIV every year in the USA - an estimated 38,500 people became infected with the virus in 2015 alone, according to the Centers for Disease Control and Prevention's latest statistics.

For the prime vaccine, used to stimulate an initial immune response, participants were injected with Ad26.Mos.HIV, which uses a strain of the common-cold virus. They recruited 393 HIV-uninfected adults age 18 to 50 from the United States, east Africa, South Africa, and Thailand between February 2015 and October 2015. The adults came from clinics across East Africa, South Africa, the USA and Thailand.

The Ad26/Ad26 plus gp140 vaccine candidate induced the greatest immune responses in humans and also provided the best protection in monkeys - resulting in complete protection against SHIV infection in two-thirds of the vaccinated animals after six challenges.

All of the vaccine combinations produced an anti-HIV immune system response and were found to be safe.

A parallel study in rhesus monkeys was also performed so that immunogenicity and protective efficacy of the various vaccines could be assessed and the optimal vaccine regimen could be realised to transfer to further clinical studies.

A new HIV vaccine is inspiring "cautious" hope in scientists after it passed human trials with "promising" results. It's unclear whether it would provide protection in humans.

Recommended

  • Trade war erupts as China fights back against U.S.  tariffs

    Trade war erupts as China fights back against U.S. tariffs

    Vehicles could be the next battleground. "So we have 50 plus 200 plus nearly 300", Trump told reporters aboard Air Force One. The US imports much more from China than the other way around, giving the US an advantage in a tariff dispute.
    West Nile Virus Found in Mosquitoes in Worcester, Auburn

    West Nile Virus Found in Mosquitoes in Worcester, Auburn

    Since 2002, there have been 64 confirmed human cases of West Nile virus in Lake County, as well as two confirmed deaths. An effective repellent will contain DEET , picaridin or oil of lemon eucalyptus.
    PM, South Korean president begin a tour of the factory

    PM, South Korean president begin a tour of the factory

    The US is saturated and Korea and Brazil are not growing significantly. "They are now looking at building a complete ecosystem. The Noida plant utilised the investment of Rs 4,915 crores which was announced by the company in June past year .
  • Sacha Baron Cohen's year-long undercover prank

    Sacha Baron Cohen's year-long undercover prank

    Then, Baron Cohen's voice - in a thick, Borat-style accent - can be heard addressing former US Vice President Dick Cheney . It also follows news from earlier this year, in which it was said that Baron Cohen was trying to get in a room with O.J.
    Ant-Man and the Wasp Gets Really Big Opening Weekend

    Ant-Man and the Wasp Gets Really Big Opening Weekend

    It's the first animated film to ever surpass $500 million at the North American box office, and the 12th film ever to do so. Universal and Amblin Entertainment's " Jurassic World: Fallen Kingdom " scored $27.6 million from 86 worldwide territories.
    North Korea: Mike Pompeo rejects 'gangster-like' accusation

    North Korea: Mike Pompeo rejects 'gangster-like' accusation

    Repatriating the remains was part of the summit agreement between Trump and Kim. "And when you want it bad, you get it bad. Pompeo was in Pyongyang last week to flesh out that deal.
  • Bihar teen rape: Principal, teacher sent to jail for fortnight

    Bihar teen rape: Principal, teacher sent to jail for fortnight

    Woman police SHO Indra Rani said the survivor would be produced before a judicial magistrate on Saturday to record her statement. The accused threatened to make the video viral if she reported the matter to anyone in the school or at her hom, she said.
    Brendon Hartley unscathed in spectacular crash at Silverstone

    Brendon Hartley unscathed in spectacular crash at Silverstone

    Ferrari's Sebastian Vettel , who was suffering a neck problem, was fourth fastest and more than a second off Hamilton's time. The condition of Hartley and his auto will need to be checked over before qualifying begins at 2pm, live on Sky Sports F1.

    Kylie Jenner Addresses Her Appearance in Response to Fan Speculation

    See the post, and the comment conversation, below! And Kylie revealed exactly why the new mum now looks like "the old Kylie ". However, he noted that Jenner could still keep her famous pucker if she got fillers just before becoming pregnant.
  • Oprah Winfrey Narrowly Avoids Fashion Disaster At Royal Wedding

    Oprah Winfrey Narrowly Avoids Fashion Disaster At Royal Wedding

    The newly minted Duchess of Sussex wore a sleeveless Brandon Maxwell sheath dress paired with Manolo Blahnik nude pumps. The pair seemed to get on brilliantly with photos of them laughing and smiling together beamed around the world.
    Nirbhaya's rapists will be hanged, SC rejects convicts' plea

    Nirbhaya's rapists will be hanged, SC rejects convicts' plea

    The Apex Court had on May 5 , last year, upheld the Delhi High court order of death penalty to them. Sept 13, 2013 remaining four accused were sentenced to death by Additional Sessions Court.
    Seattle bans straws and utensils made of plastic

    Seattle bans straws and utensils made of plastic

    Businesses that sell food or drinks won't be allowed to offer the plastic items under a rule that went into effect Sunday . California's Legislature is considering statewide restrictions, but not an outright ban, on single-use plastic straws.

Trump Builds Suspense Over Supreme Court Pick, but Battlelines Are Already Drawn He recently voiced disagreement with a court decision allowing an undocumented teenage immigrant to get an abortion. The bottom line: Judge Barrett has given every indication that she will be an activist judge on the Court.

Lebanese woman sentenced to eight years for 'insulting' Egypt Lebanese woman sentenced to eight years for 'insulting' Egypt Mazbouh fiercely criticized the way she had been treated, claiming she was "harassed by taxi drivers and men in the street". Tourist Mona el-Mazbouh complained about sexual harassment in profanity-laced video, with Egyptians responding in kind.

Hammers sign former Arsenal star Wilshere on free transfer Hammers sign former Arsenal star Wilshere on free transfer The 26-year-old had a number of suitors for his signature but was lured to the London Stadium by Pellegrini's vision. West Ham have signed Fabián Balbuena from Brazilian side Corinthians on a four-year contract.

Avengers : Infinity War - details on a lovely scene epic abandoned Avengers : Infinity War - details on a lovely  scene epic abandoned Let's hope he doesn't take it too hard, who knows what it could mean for the production of Avengers 4 . One subreddit will soon be perfectly balanced, as all things should be.

Fearless France ready to show Belgium's Henry he picked wrong side Fearless France ready to show Belgium's Henry he picked wrong side Marouane Fellaini has made one of the midfield spots his own since his game changing performance against Japan last week. For the French to land it, they'll have to end Belgium's 24-match unbeaten run which comprises 19 wins and five draws.

The Queen and Prince Philip will not attend Prince Louis's christening The Queen and Prince Philip will not attend Prince Louis's christening James's Palace in London , Prince George was dressed up in the newly made replica of the classic Victorian christening gown. However, his great-grandmother the queen and her husband Prince Philip will not be among the guests, Kensington Palace said.

London ambulance damaged as England fans celebrate World Cup quarter-final win Footage from Clapham, south London, sees a fan plunge through a glass bus stop roof after leaping from the top of a double-decker bus.

Alonso backs Brown, distances himself from changes Alonso backs Brown, distances himself from changes Zak Brown says that "pressure" on McLaren led to the departure of team boss Eric Boullier . As for whether Boullier's existing role will be replaced, Brown said that he is unsure.

Trump lawyers called Comey 'Machiavellian' in note to Mueller Trump lawyers called Comey 'Machiavellian' in note to Mueller The biggest question hanging over the investigation right now is whether or not Trump will sit down with Mueller for an interview. Trump's tweets are the result of the president finally having the time to turn his attention to this issue and because Mr.

Philippine president vows to resign if anybody can prove God exists Philippine president vows to resign if anybody can prove God exists Duterte lamented in that speech that Adam and Eve's sin in Christian theology resulted in all the faithful falling from divine grace.

Britain's Brexit minister David Davis steps down Britain's Brexit minister David Davis steps down In her reply, Mrs May said: "I do not agree with your characterisation of the policy we agreed at cabinet on Friday". She said the government's Brexit plan was "far from perfect" but marked "grown-up steps".

Robin Wright on Kevin Spacey: 'I didn't know the man' Robin Wright on Kevin Spacey: 'I didn't know the man' Australian actor Guy Pearce says the disgraced actor was "handsy" during their time together on LA Confidential . He said: "The older I get, and the more I know, I feel very fortunate that something worse didn't happen.

I didn't really know the man: Robin Wright on Kevin Spacey I didn't really know the man: Robin Wright on Kevin Spacey Wright, who plays lead character Claire Underwood, spoke of Spacey's departure while appearing on the Today show Monday. Production was halted on House of Cards season 6 while the show reconfigured the season without Spacey .

Political head butting: Prime Minister and Ontario Premier meet Political head butting: Prime Minister and Ontario Premier meet Ontario's former Liberal government signed an immigration agreement with Ottawa in November of past year . Tory reiterated his pleas for assistance from the federal government.

Brexit minister Davis steps down in big blow to May Brexit minister Davis steps down in big blow to May Davis said he had left because he feared the European Union would "take what we have offered already and then demand some more". He said he was anxious the government's negotiating approach would "lead to further demands for concessions" from Brussels.