Monday, 16 July, 2018

An artificial ovary for fertility preservation without the risk of reintroducing malignancy

An artificial ovary for fertility preservation without the risk of reintroducing malignancy Artificial human ovaries created for first time in major breakthrough for infertile women
Anna Jefferson | 05 July, 2018, 03:33

These artificial ovaries could even help the women having health conditions like the blood ailment beta thalassemia or multiple sclerosis, which usually need dynamic fertility-harming treatments.

The procedure would ostensibly be used by women undergoing toxic cancer treatments such as chemotherapy, which has the potential to cause infertility.

However, there is a slight risk that the ovarian tissue may contain cancer cells, putting a woman at risk for the return of her cancer.

Hence, to combat such a risk completely, the researchers from the Rigshospitalet in Copenhagen chose to develop artificial ovaries for patients who were due to undergo cancer treatment.

Commenting on the research, Professor Nick Macklon, medical director at London Women's Clinic, said it was an "exciting development". Pors, on Monday, would be addressing and telling in a yearly meeting of the European Society of Human Reproduction and Embryology at Barcelona, about the method with which the team implanted the artificial ovary.

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Dr Susanne Pors, who presented the research, said: "This is the first time that isolated human follicles have survived in a decellularised human scaffold and, as a proof-of-concept, it could offer a new strategy in fertility preservation without risk of malignant cell recurrence". This left a decellularized scaffold consisting of proteins and collagen. The team developed the scaffold over three-days by using chemicals to strip the ovarian tissue of all of its cells. This new method shows promise for women undergoing cancer treatments who are wanting to conceive after their treatment.

The Daily Telegraph reported that the "artificial ovary" was implanted into a mouse, and the process succeeded after several attempts.

Though this approach might work, he concluded that "it is not possible to tell until the data from this research group have been peer-reviewed by the scientific community and published in a scientific journal". Although the risk is quite low, yet women with specific kinds of cancer could not get this treatment. Which were collected from cancer patients.

He said the technique was "likely to develop into something that will be potentially useful", but said further research was needed to prove it will work in humans.

This is perhaps the only treatment for preserving fertility in women. Renewed hormonal function occurred in 95% of these women, and more than 100 children have been conceived after the tissue transfers.

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