Saturday, 18 August, 2018

Immune System drug shows 'spectacular' results for Prostate Cancer patients

Immune System drug shows 'spectacular' results for Prostate Cancer patients Immune System drug shows 'spectacular' results for Prostate Cancer patients
Anna Jefferson | 06 June, 2018, 12:53

However, the researchers discovered that the latest trial will not be able to help majority of men and only a particular group of patients may only be able to benefit from this treatment based on the genetics of the tumours.

The new study involved trial of 258 men, and the trial was conducted jointly by the Institute of Cancer Research, London, and the Royal Marsden NHS Foundation Trust. However, more than a third of those men who have been treated with a new drug, could stop the proliferation of malignant cells.

Professor Johann de Bono says, "I have these men who are dying, with weeks to months to live, whom we gave this drug to and had complete responses".

Data from nine trials including more than 8,000 men with advanced prostate cancer showed that survival for black men was initially the same as for white men - an average of 21 months.

With this study, George and colleagues hypothesized that black men with advanced prostate cancer would respond better to abiraterone than white men.

Earlier trials on using immunotherapy in prostate cancer have been unsuccessful.

"Our study provides prospective evidence that there might be inherited genes that could affect treatment response and track with African ancestry in prostate cancer patients", George said.

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"This is the first prospective multicenter study by race of an anti-androgen hormonal therapy in advanced prostate cancer", George said.

Immunotherapy has become a treatment for cancer, particularly skin and lung cancers.

The researchers suggest these mutating cancer cells may be easy for the immune system to recognise and attack because they look different from healthy cells.

"It's exciting that immunotherapy could offer some men more time with their loved ones where they have such advanced disease that they have run out of existing treatment options".

Some patients whose bodies were riddled with cancer have had "Lazarus-like" recoveries - and now show no visible signs of disease 18 months or more later, according to the doctor leading research into the treatment. Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system. This study should serve as a call for the entire cancer research community to make trials much more inclusive. It seems to work incredibly well for a handful of patients, have a temporary effect in others, and do nothing for the rest.

"One of the major challenges with immunotherapy is that we don't have many reliable tests to pick out who will benefit", Workman said.

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