Thursday, 20 September, 2018

Can herpes virus cause Alzheimer's disease?

Courtesy MGN Online Courtesy MGN Online
Anna Jefferson | 25 June, 2018, 07:24

They found that numerous genes that clicked on during Alzheimer's are the same genes that activate when the body is fighting a virus.

Exploring the significance of viruses in the brain is still at its early stages, and a key question is whether pathogens play an active role in causing disease or are opportunistic, taking advantage of neural deterioration. The researchers found higher levels of HHV-6A and HHV-7 in Alzheimer's patient brain samples compared with brains unaffected by Alzheimer's.

It has always been a controversial theory about Alzheimer's disease, often dismissed by experts as a sketchy cul-de-sac off the beaten path from mainstream research. After an 18-month study examining the effects of nutritional compounds found in foods such as trout, broccoli and peppers on people with Alzheimers, the team from the Nutrition Research Centre Ireland (NRCI) claims to have done a ‘statistically significant finding. However, one controversial theory asserts that Alzheimer's may be caused by numerous viruses that affect the brain. The study in no way suggests that Alzheimer's disease is contagious or can be passed from person to person like a virus - or that having cold sores increases a person's risk of dementia.

Nobody really knows what causes Alzheimer's disease. While this discovery surprised the researchers, they continued to follow the path and what they learned was that the genes were "two incredibly common and closely related herpesviruses that are known to cause childhood rashes and fevers", and they are so common that nearly everyone has them. "But what's clear is that they're perturbing networks and participating in networks that directly accelerate the brain towards the Alzheimer's topology". But still, the findings of the study open doors for new treatment options for a disease which has many of failed trails.

'I'm not "effing" around': Tom Arnold shuts down during an interview
He told NBC News that tweeting the photo was "indiscreet" but said Cohen had been betrayed by Trump after years of loyal service. Arnold is working on a new documentary for Vice Media , in which he searches for more unflattering tapes featuring Trump.

Rose Leslie's Lace Wedding Dress Is Flawless
It appears, both Kit Harington and Rose Leslie curated a guest list that ensured a Game Of Thrones reunion in Scotland . They played love interests who ultimately were on opposite sides of a power struggle.

Zsa Zsa, the English bulldog, wins World’s Ugliest Dog title
The 30th World's Ugliest Dog Contest took place this weekend and there were some outstanding entries. Here's what our winning pup's profile had to say about her life before World's Ugliest Dog stardom.

The researchers in the new study looked at data on 622 brains from people who had had signs of the disease and 322 from people who did not seem to be affected by it. In fact, in North America, approximately 90% of children have at least one of the strains in their blood in their early lives. In most cases, though, the virus is latent. "It therefore doesn't change what we already know about the causes of dementia, doesn't mean that having cold sores put you at increased risk of getting it and people shouldn't be unduly anxious".

They found a lot of interactions, suggesting the viruses could even switch on and off Alzheimer's-related genes. Rather, the findings show viral DNA sequences and activation of biological networks - the interrelated systems of DNA, RNA, proteins and metabolites - may interact with molecular, genetic and clinical aspects of Alzheimer's.

"All these Alzheimer's brains in these separate, major brain banks have previously unsuspected substantial populations of herpesvirus genomes and that deserves an explanation wherever it falls in the pathogenesis", Gandy said.

Recommended

Ex-MLB all-star being "eyed" in federal drug trafficking investigation Ex-MLB all-star being Ramirez, the Red Sox, and Major League Baseball have all denied knowledge of any current investigation. In May, Ramirez was designated for assignment by the Red Sox .

People angry over Sanders slam the wrong Red Hen Trump's hardline stance on families trying to enter the USA from Mexico has hardened political differences across America. Lexington is located about 190 miles (304 kilometers) south west of the nation's capital, in the rural Shenandoah Valley.

First Lady Melania Trump's jacket sparks controversy Photogallery First Lady Melania Trump's jacket sparks controversy Photogallery Bush and Barack Obama were to blame for an immigration controversy that has been created by the current administration. A Border Patrol Agent was injured on Saturday during protests at an immigrant detention facility in McAllen, Texas.

Lesandro Guzman-Feliz, Slain Bronx Teen’s Family Creates GoFundMe Page Lesandro Guzman-Feliz, Slain Bronx Teen’s Family Creates GoFundMe Page NY police officers stand guard at the street while demonstrators protest against President Trump in Bethpage, May 23, 2018. Guzman-Feliz, affectionately known as Junior, was described as a "good kid" by family and community members.

Trump tweet may doom House Republicans' effort on immigration Trump tweet may doom House Republicans' effort on immigration Sanders tweeted Friday: "It's shameful that dems and the media exploited this photo of a little girl to push their agenda". If a bill makes it through the House, it would still have to be supported by several Senate Democrats to pass both houses.

Lesandro Guzman-Feliz Death Lesandro Guzman-Feliz Death Lesandro "Junior" Guzman-Feliz's mother, Leandra Feliz, said to the Daily News , "He was one of the good kids in the Bronx". Rapper Cardi B , a Bronx native, was among those paying tribute, posting on Instagram about getting justice for the teen.

Mohamed Salah 'happy in camp' says Egyptian FA Mohamed Salah 'happy in camp' says Egyptian FA But his global future will now be under consideration as a result of the events in Chechnya during the tournament. Reports criticized Kadyrov for using Salah for propaganda purposes, which the Chechen leader firmly denied.

OH police officer fired for falsely arresting daughter, daughter's boyfriend OH  police officer fired for falsely arresting daughter, daughter's boyfriend He told investigators he did not approve of his daughter's relationship with Coleman, but didn't give a reason. Kovach tells his daughter to get in the driver's place, but she objects, saying she is 18 and an adult.

Driver of autonomous Uber streaming 'The Voice' just before crash Driver of autonomous Uber streaming 'The Voice' just before crash According to the police report, Vasquez was distracted in this way for seven of the almost 22-minutes just prior to the collision. A video of the moments before the crash shows Vasquez looking toward her right knee while occasionally looking up and around.

World Cup rout for England over Panama World Cup rout for England over Panama However, the biggest cheer of the day was reserved for the 78th minute when Felipe Baloy scored Panama's first ever finals goal. Unsurprisingly, this would not produce a victor if Belgium and England draw. "Obviously it's been going well so far".

SpaceX wins $130 million Air Force contract SpaceX wins $130 million Air Force contract It's not immediately clear what role the classified satellite on this mission, AFSPC-52, will play when it is launched in 2020. It has already won five previous contracts since its rockets were certified to fly military missions.

Colombia boost World Cup last-16 hopes by eliminating Poland Colombia boost World Cup last-16 hopes by eliminating Poland There will be a weight of expectation on his shoulders when Colombia face Senegal in their final group game on Thursday. Poland has now failed to keep a clean sheet in its last 10 World Cup matches, since beating Portugal 1-0 in 1986.

Trump adviser questions Abbas desire for peace with Israel Trump adviser questions Abbas desire for peace with Israel Israel considers the eastern sector, home to sites sacred to Jews, Christians and Muslims, as an inseparable part of its capital. Kushner says the plan is "almost done", but offered scant details aside from the promise of economic prosperity.

Goerges marches past Barty into Birmingham quarterfinals Goerges marches past Barty into Birmingham quarterfinals But she also lost to Strycova at Eastbourne a week later a year ago before going on to win Wimbledon . The Czech next faces Julia Gorges or Nottingham Open victor Ashleigh Barty .

Could Iran possibly spring surprise on Spain and Portugal? Could Iran possibly spring surprise on Spain and Portugal? Team Melli now need a result against Portugal in their final Group B game on Monday to force their way into the knockout rounds. BBC Sport's pundit Chris Sutton wrote about the match, " Iran are what the World Cup is all about: pride, passion and drive".