Cochrane Review Backs HPV Vax For Girls, Young Women
Cochrane Review Backs HPV Vax For Girls, Young Women
HPV vaccine prevents cervical cancer
10 May, 2018, 12:21
"Most women aged 15 to 25 years in the United Kingdom have now received the HPV vaccine", she said. In some women, an HPV infection will persist and lead to cervical cancer.
Vaccines created to prevent infection with human papillomavirus (HPV) are effective in protecting against pre-cancerous cervical lesions in women, particularly in those vaccinated between age 15 and 26, according to a large global evidence review.
All people who are sexually active at some point will be exposed to the HPV virus.
"Data of single-dose effectiveness can be highly useful in informing the most cost-effective approach to HPV vaccination and global public health policy", Lynch said.
The report's authors, who examined evidence from 26 previously published studies of more than 70,000 women, also found no serious side effect risks associated with the vaccines.
In women between the ages of 15 and 25 who tested negative for HPV before receiving the vaccine, the risk of precancer associated with HPV16 or HPV 18 was 164 for every 10,000 unvaccinated women, compared with just two per 10,000 vaccinated women.
These pre-cancerous lesions can progress to cervical cancer if left untreated. All investigations were well designed, dividing individuals into HPV vaccinations or not.
In older women who were vaccinated between 25 and 45 years, the vaccine was not as effective.
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The authors found that there was no increased risk of miscarriage among women who became pregnant during the studies (RR 0.88, high certainty) or termination (RR 0.90, high certainty), but noted an "uncertain" effect on congenital abnormalities (RR 1.22, moderate certainty) and stillbirths (RR 1.12, moderate certainty).
Cochrane lead author, Dr. Marc Arbyn, from the Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, said: "The findings of this review should be viewed within the context of multiple global surveillance studies, which have been conducted by the Global Advisory Committee on Vaccine Safety from the World Health Organization since the vaccinations were licensed".
"The Scientific Committee concludes that the risk-benefit profile of HPV prophylactic vaccination remains in favor of the benefit and expresses its concern about the non-existent claims that it poses risks as there are no biological and epidemiological evidence but can affect its confidence public". Thus, the authors said they made "particular effort" to assess severe adverse effects to provide healthcare professionals and patients with the potential benefits, and the potential harms, of HPV vaccines.
Consultant in gynaecological oncology at Musgrove Park Hospital Dr Jo Morrison said: 'These data show that immunising against HPV infection protects against cervical pre-cancer, and it is very likely that this will reduce cervical cancer rates in the future.
"This, together with early evidence of reduction in cervical cancer in Finland, confirms the groundbreaking value of this cancer-preventing vaccine", said Bedford, who was not involved in the study.
She added: 'Cervical cancer can take many years to develop following HPV infection and development of pre-cancer lesions, therefore long-term follow-up studies are needed to find out the effects of HPV vaccination on cervical cancer rates'.
HPV can also cause oral, anal and penile cancer. "In time, it is expected that the vaccine will save hundreds of lives every year". The risk of precancer associated with HPV16/18 is probably lowered from 145/10,000 in unvaccinated women to 107/10,000 following HPV vaccination (moderate certainty).
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