Wednesday, 23 May, 2018

Certain antibiotics increase kidney stone risk

Small children are prescribed antibiotics more than any other group Small children are prescribed antibiotics more than any other group
Anna Jefferson | 12 May, 2018, 22:24

He says high-risk children, like those who've already had a kidney stone, should probably take antibiotics that are less associated with stones. Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

"Everyone thinks you're older when you get them, so no one believed it when I said I had kidney stones", said Gaal.

United States pediatric researchers found that children and adults treated with certain antibiotics had a greater risk of developing kidney stones. Researchers at the Pediatric Hospital in Philadelphia wanted to know if certain antibiotics could increase the development of kidney stones. This can also get a solution to reduce the risks of kidney stones as well. They include widely prescribed drugs like Bactrim, Keflex, Cipro, Augmentin, and amoxicillin. But prior research has cited a possible association with disturbances in the bacterial makeup (microbiome) of the intestinal and urinary tracts, which is often sparked by antibiotics. "So if they were prescribed at, say, 15 years of age, the risk was much higher than if it was prescribed later in life", said Dr. Tasian.

Now, that the link has been established between antibiotics and stones. The results of their study appeared in the Journal of the American Society of Nephrology.

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The exact reason why kidney stones are on the rise is unknown, but the study has found that antibiotic intake may play a key role, especially considering the fact that children are given more antibiotics than adults.

The data included the treatment history of 26,000 individuals with kidney stones, which the team compared with the health records of nearly 260,000 people who had not developed kidney stones (the controls).

After adjusting for mitigating factors such as other medication use and being diagnosed with a urinary tract infection, diabetes or gout, they found that sulfas, cephalosporins, fluoroquinolones, nitrofurantoin/methenamine and broad-spectrum penicillins were all associated with a heightened risk of kidney stones, when taken three to 12 months before diagnosis. The drugs ranged from broad-spectrum penicillins, which increased the risk by 27 percent, to sulfa drugs, which were associated with more than double the risk. The risk of nephrolithiasis decreased over time, but it remained elevated at 3-5 years after the antibiotic prescription.

Conclusions Oral antibiotics associated with increased odds of nephrolithiasis, with the greatest odds for recent exposure and exposure at younger age. Previous research has shown that children receive more antibiotics than any other age group, and 30 percent of antibiotics prescribed during ambulatory care visits are inappropriate.

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