Baldness cure could come from side-effect of cancer drug
Baldness cure could come from side-effect of cancer drug
NewsScienceHas baldness finally been cured?Joe Mellor
09 May, 2018, 10:27
Both have side effects and often produce disappointing hair regrowth results, the researchers noted.
Male pattern baldness is the most common cause of hair loss, which experts say can be extremely distressing for men.
It blocks a naturally-occurring protein that prevents growth and induces male baldness.
"The fact this new agent, which had never even been considered in a hair loss context, promotes human hair growth is exciting because of its translational potential: It could one day make a real difference to people who suffer from hair loss".
Now only two drugs, minoxidil and finasteride, are available for the treatment of male pattern baldness (androgenetic alopecia) - the classic type of receding hair-line hair loss in men.
Hawkshaw said the next step should be a clinical trial to determine whether WAY-316606, or similar compounds, are effective and safe.
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As of now the only two drugs are approved to be used to treat hair loss, which are: minoxidil, which is found Rogaine, and finasteride, found in the products, Propecia and Proscar.
After some detective work, Dr Hawkshaw found that a compound originally developed to treat osteoporosis, called WAY-316606, targets the same mechanism as CsA by specifically antagonising SFRP1.
For the experiments, scalp hair follicles from over 40 patients were obtained through the means of a collaboration with British hair transplant surgeon Dr. Asim Shahmalak from Crown Clinic, U.K.
This medication, Cyclosporine A (CsA), has been commonly used as the 1980s to curb transplant rejection and autoimmune illnesses. The researchers treated the follicles with the drug and saw that the hair growth as enhanced.
"That creates our analysis clinically really relevant, as most hair loss lookup studies merely utilize cell civilization", he explained. Not only this, we show that this drug effectively enhances hair shaft keratin production. Hair growth, however, is the least problematic side-effect of CsA, leading project leader, Nathan Hawkshaw, to look for another solution.
He added: 'Interestingly, when the hair growth-promoting effects of cyclosporine A were previously studied in mice, a very different molecular mechanism of action was suggested.
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