Thursday, 19 July, 2018

Baldness cure could come from side-effect of cancer drug

Around four in 10 men suffer male pattern baldness by the age of 45 and two thirds by the age of 60 Around four in 10 men suffer male pattern baldness by the age of 45 and two thirds by the age of 60
Anna Jefferson | 09 May, 2018, 10:27

Both have side effects and often produce disappointing hair regrowth results, the researchers noted.

Male pattern baldness is the most common cause of hair loss, which experts say can be extremely distressing for men.

It blocks a naturally-occurring protein that prevents growth and induces male baldness.

"The fact this new agent, which had never even been considered in a hair loss context, promotes human hair growth is exciting because of its translational potential: It could one day make a real difference to people who suffer from hair loss".

Now only two drugs, minoxidil and finasteride, are available for the treatment of male pattern baldness (androgenetic alopecia) - the classic type of receding hair-line hair loss in men.

Hawkshaw said the next step should be a clinical trial to determine whether WAY-316606, or similar compounds, are effective and safe.

Pacific Passenger Vehicle SLI Battery Market 2018: Industrial Analysis and Forecasts 2025
This report is prepared using data sourced from in-house databases, secondary and primary research team of industry experts. The Motorcycle Battery market report shows a significant growth in the CAGR during the forecast period 2018 to 2023.

Rooney in talks with DC United
United when the Major League Soccer's transfer and trade window opens on July 10. It's claimed that the forward is in serious talks to join D.C.

Iran nuclear deal: 3 key points
Especially when USA intelligence officials, including ex-CIA chief, now Secretary of State, Mike Pompeo say Iran is in compliance. To Trump's critics, abandoning the Iran agreement will only teach North Korean leader Kim Jong Un that the USA can't be trusted.

As of now the only two drugs are approved to be used to treat hair loss, which are: minoxidil, which is found Rogaine, and finasteride, found in the products, Propecia and Proscar.

After some detective work, Dr Hawkshaw found that a compound originally developed to treat osteoporosis, called WAY-316606, targets the same mechanism as CsA by specifically antagonising SFRP1.

For the experiments, scalp hair follicles from over 40 patients were obtained through the means of a collaboration with British hair transplant surgeon Dr. Asim Shahmalak from Crown Clinic, U.K.

This medication, Cyclosporine A (CsA), has been commonly used as the 1980s to curb transplant rejection and autoimmune illnesses. The researchers treated the follicles with the drug and saw that the hair growth as enhanced.

"That creates our analysis clinically really relevant, as most hair loss lookup studies merely utilize cell civilization", he explained. Not only this, we show that this drug effectively enhances hair shaft keratin production. Hair growth, however, is the least problematic side-effect of CsA, leading project leader, Nathan Hawkshaw, to look for another solution.

He added: 'Interestingly, when the hair growth-promoting effects of cyclosporine A were previously studied in mice, a very different molecular mechanism of action was suggested.

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