Monday, 15 October, 2018

Ibuprofen and Infertility in Men Linked by Study

REX  Shutterstock REX Shutterstock
Anna Jefferson | 12 January, 2018, 20:01

Of the group of men ages 18 through 35, 14 of them were given 600 milligrams twice a day. Higher-than-normal levels of luteinizing hormone can indicate a problem with the testes, according to the National Institutes of Health.

Levels of luteinising hormone, which stimulates the testosterone production increased in the study participants but overall testosterone dropped. "Ibuprofen puts a severe damper on testosterone production, so the brain has to kick in", said David Møbjerg Kristensen, a senior researcher at the Copenhagen's main hospital, Rigshospitalet. Ibuprofen showed an inhibitory effect on testosterone production in these cells too. This would lead to continuously low levels of testosterone, because the body could no longer compensate for the fall. And the problem is not likely to be ibuprofen-specific, as most NSAIDs work through similar mechanisms. In a recent study by researchers, ibuprofen has been contributing to the deterioration of male fertility upon long-term exposure.

The human brain compensates for testosterone deficiency by producing luteinizing hormone (LH), which sends a signal to the testicles to produce more testosterone.

Male fertility is dropping around the world and the researchers wanted to see if ibuprofen might be contributing to this. Particularly in western countries, where some counts have drastically plunged over the last 40 years.

The best way to address a low testosterone level is with artificial hormones.

A study of nearly 1,000 men tracked for seven years found nearly twice as many with testosterone deficiency - or hypogonadism - died as did those with normal levels.

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Speaking to Turkish daily Habertürk, Physical Therapy and Rehabilitation Specialist Özgül Bozkurt Tuncer said that Ibuprofen is regularly used in the field of rehabilitation, but she prefers not to prescribe it due to its short-term effects on the kidneys and liver.

The chances of conceiving, according to the Mayo Clinic, are bettered by increasing the frequency of sex at least four days before a woman's ovulation and avoiding the use of lubricants, as certain ingredients can affect the quality of sperm.

Read through our gallery on erectile dysfunction and the possible causes.

"Long-term use of ibuprofen has other negative effects on overall health so people should only be taking it over a period of weeks, months or years if a doctor has prescribed it".

Compensated hypogonadism usually only affects the elderly or smokers, but taking ibuprofen increases a younger person's risk.

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