Saturday, 20 January, 2018

Do Oral Contraceptives Actually Increase Breast Cancer Risk?

The actress Angelina Jolie had a pre-emptive mastectomy after finding out that she had a BRCA gene mutation The actress Angelina Jolie had a pre-emptive mastectomy after finding out that she had a BRCA gene mutation Christopher Polk  Getty Images
Anna Jefferson | 12 January, 2018, 21:05

The good news for young women who carry the infamous BRCA1 or BRCA2 gene is that their chances of survival after conventional breast cancer treatment are the same as those who don't have the mutation.

Professor Peter Fasching, from Friedrich-Alexander University Erlangen-Nuremberg, Germany, added: "This important topic needs more prospective research as preventive surgical measures might have an effect on what might be a very long life after a diagnosis of breast cancer at a young age".

Martin Ledwick, Cancer Research UK's Head Information Nurse, said: "Although BRCA faults increase the risk of young women developing cancer, their outlook once diagnosed is no worse than that for young women with breast cancer who don't carry the BRCA gene faults". The faulty gene increases the risk of a woman developing breast and ovarian cancers, with 45% to 90% of women with the mutation developing breast cancer during their lifetime, compared to roughly 12.5% of women in the general population.

And in women under the age of 40 diagnosed with breast cancer, a higher proportion have these faulty genes compared with older patients.

The women's medical records were tracked for up to 10 years.

"Our findings suggest that this surgery does not have to be immediately undertaken along with the other treatment".

Dollar Tree Inc (NASDAQ:DLTR) Stock Through Resistance -- Technicals Hit Extreme Strength
As of January 28, 2017, the Company operated 14,334 stores in 48 states and the District of Columbia, and five Canadian provinces. It fall, as 45 investors sold Dollar Tree, Inc . shares while 191 reduced holdings. (NASDAQ:PFPT) or 270,688 shares. (NYSE:KR).

Occidental Petroleum Corp (OXY) Shareholder Cypress Capital Management LLC Lowered Its Holding
Mcf Advisors Ltd Limited Liability Company reported 3,475 shares stake. 4,695 shares were sold by Tharby Linda M, worth $941,254. Flossbach Von Storch AG raised its position in shares of Occidental Petroleum by 179.7% during the second quarter. (NASDAQ:FB).

Zacks Investment Research Upgrades Valley National Bancorp (NYSE:VLY) to "Hold"
It worsened, as 73 investors sold AMZN shares while 549 reduced holdings. 35 funds opened positions while 91 raised stakes. Ledyard National Bank sold 924 shares as the company's stock rose 13.58% with the market. (NYSE:AIG) for 128 shares.

During this time, 651 of the women died from breast cancer, and those with the BRCA mutation were equally likely to have survived at the two-, five- and 10-year mark as those without the genetic mutation.

For this study, researchers followed more than 2,700 women recruited from more than a hundred British hospitals for almost a decade. Most importantly, they uncovered that there was no difference in overall survival two, five, or ten years after diagnosis for women with and without a BRCA mutation.

'This study can reassure young women with breast cancer ... that breast conservation with radiotherapy is a safe option in the first decade after diagnosis and double mastectomy is not essential or mandatory at initial treatment.

About a third of those with the BRCA mutation had a double mastectomy to remove both breasts after being diagnosed with cancer, the same surgery Jolie went through.

"Together, BRCA1 and _BRCA_2 mutations account for about 20 to 25 percent of hereditary breast cancers and about 5 to 10 percent of all breast cancers", the National Cancer Institute says. "These risks determine treatment, and knowing that BRCA1 or BRCA2 mutations do not result in a different prognosis might change the therapeutic approach for these risks". It is also approved in the USA for advanced ovarian cancer patients who have received at least three prior lines of chemo and maintenance treatment of ovarian cancer in patients who are in complete or partial response to platinum-based chemo, both BRCA-positive. On Friday, the Food and Drug Administration announced that the agency was expanding its approval for a drug called Lynparza to treat breast cancer in people who were BRCA carriers.

Recommended

  • Intel presents drone light show over Bellagio Fountains this week

    Intel presents drone light show over Bellagio Fountains this week

    A dozen or so took the stage and danced above a projected piano, playing a tune reminiscent of Tom Hanks' performance in Big. The display followed Intel CEO Brian Krzanich's keynote speech at the Park Theater at Monte Carlo.
    John Cena & Nickelodeon Make 2018 Plans, Including Kids Choice Awards Hosting Gig

    John Cena & Nickelodeon Make 2018 Plans, Including Kids Choice Awards Hosting Gig

    THR reports John Cena's character will be recurring and debuts in the premiere episode and will be featured throughout the series. It was announced today that John Cena will be returning to host Nickelodeon's Kids Choice Awards this year.
    Trump says fairer deal might coax US back to Paris climate accord

    Trump says fairer deal might coax US back to Paris climate accord

    Moreover, the agreement hurt United States businesses overall and gave advantages to other countries such as China, Trump added. Standing alongside Norwegian Prime Minister Erna Solberg , Trump presented himself as a champion of environmentalism.
  • Florida's Children's Health Insurance Program faces uncertainty

    Florida's Children's Health Insurance Program faces uncertainty

    It cost $15 billion in 2016, according to data from the Kaiser Family Foundation . Funding for the program in MA in now expected to run out by April.
    Ablynx rejects EUR2.6bn takeover offer from Novo Nordisk

    Ablynx rejects EUR2.6bn takeover offer from Novo Nordisk

    Novo Nordisk said it made an initial offer in December and then raised it, but that it had been rejected by Ablynx's managment. Novo Nordisk, the world's biggest insulin maker, is seeking to diversify its product offerings in a competitive market.

    British American Tobacco (BTI) Upgraded to "Buy" by Zacks Investment Research

    Societe Generale upgraded British American Tobacco PLC from a "hold" rating to a "buy" rating in a report on Friday, October 28th. It turned negative, as 49 investors sold EL shares while 211 reduced holdings. 61 funds opened positions while 194 raised stakes.
  • Houthi rebels say they fired ballistic missile at Saudi Arabia

    Houthi rebels say they fired ballistic missile at Saudi Arabia

    It is the fifth long-range ballistic missile attack by the Yemeni Houthi rebels on the neighboring oil-rich Gulf state in two months.
    Penn National Gaming (NASDAQ:PENN) Upgraded to Strong-Buy at BidaskClub

    Penn National Gaming (NASDAQ:PENN) Upgraded to Strong-Buy at BidaskClub

    Ashfield Ptnrs Limited Liability Company has 255,757 shares. 20,000 shares were sold by Sottosanti Carl, worth $440,000. The stock of Atlantic Power Corporation (NYSE:AT) has "Hold" rating given on Monday, July 27 by Canaccord Genuity.

    Evercore ISI Begins Coverage on Mettler-Toledo International (MTD)

    Voya Management Limited Company invested in 16,710 shares or 0% of the stock. (NYSE:MTD) on Tuesday, September 8 to "Buy" rating. Chartwell Investment Partners LLC raised its position in shares of Mettler-Toledo International by 21.7% in the second quarter.
  • Rain Moves In, Then Cold Air Returns

    Rain Moves In, Then Cold Air Returns

    Friday night , there is a 30 percent chance of snow after 1 a.m., with a low of 12, according to the weather service. Day: Cloudy with a 40 percent chance for sleet and freezing rain in the morning changing to rain in the afternoon.
    Congressional Leaders, White House Huddle On Budget

    Congressional Leaders, White House Huddle On Budget

    DACA was established by an executive order issued by President Obama, but repealed by President Trump in September . On the campaign trail, he called it "illegal amnesty" and promised to terminate the program immediately if elected.
    Homeowners Encouraged To Test For Radon

    Homeowners Encouraged To Test For Radon

    These tests provide a better idea of what you home's year-round average radon level is. The cost of a radon mitigation system can vary, but typically runs around $1,200.

Who is Shane Lynch? Celebrity Big Brother 2018 contestant profile Who is Shane Lynch? Celebrity Big Brother 2018 contestant profile Meanwhile, host Emma Willis struggled to compose herself, saying: "I think we've just peaked, haven't we?" Some said it was a staged incident.

Region's aggregate house sale price up 25%: Royal LePage Region's aggregate house sale price up 25%: Royal LePage Prices of condos in Vancouver increased 18.7 per cent year-over-year, from $653,794 in Q4 2016 to $775,806 in Q4 2017. Aggregate prices are calculated using a weighted average of the median values of all housing types collected.

Patterson-UTI Energy, Inc Pennant Capital Management Llc increased Hostess Brands Inc stake by 63,400 shares to 789,045 valued at $10.78 million in 2017Q3. The Pennant Capital Management Llc holds 833,892 shares with $36.37 million value, down from 956,792 last quarter.

New York Islanders vs. Boston Bruins - 1/2/18 NHL Pick, Odds, and Prediction New York Islanders vs. Boston Bruins - 1/2/18 NHL Pick, Odds, and Prediction Jordan Eberle had New York's goal and Jaroslav Halak finished with 33 saves as the Islanders lost their third straight. Rask is in the midst of an 11-game point streak (10-0-1) - which stands as the longest streak of his career.

Is GlaxoSmithKline (NYSE:GSK) now a 'Sell' After a Merrill Lynch Downgrade? To measure price-variation, we found GSK's volatility during a week at 1.31% and during a month it has been found around 0.94%. Glaxosmithkline Plc (NYSE:GSK) now has a Weekly Volatility of 1.01% percent while its Monthly Volatility is at 0.96% percent.

Trump weighs-in on Oprah's potential presidential run Trump weighs-in on Oprah's potential presidential run But if politics is a money game, then the odds are still long. "But I don't think she's actively considering it at this time". Winfrey appeared on CBS's "This Morning" in October to talk about a story she worked on as a correspondent for "60 Minutes".

Titans beat Chiefs, 22-21, in epic playoff comeback Titans beat Chiefs, 22-21, in epic playoff comeback Losing the former Dallas Cowboy is a big blow considering they have to play near ideal football to win this game. PROMISING YOUNGSTERS: The Chiefs have reason for optimism in that most of their biggest stars are young.

Leonardo Jardim gave an update on Thomas Lemar's situation last night Leonardo Jardim gave an update on Thomas Lemar's situation last night Whether either club offers a deal that they can not say no to is yet to be seen but they seem to be open to decent offers. The Frenchman almost joined the Gunners in the summer transfer window but a late move on deadline day fell through.

Facebook, Apple, GM leaders urge Congress to protect 'Dreamers' Facebook, Apple, GM leaders urge Congress to protect 'Dreamers' On Tuesday, a judge temporarily blocked the Trump administration from ending DACA, but the Department of Justice plans to appeal. Economists estimate that a failure to act could cost the economy $215 billion in GDP, the executives' letter added.

Intel has hit a "major breakthrough" in quantum computing Intel has hit a Loihi put training and inference onto a single chip, which Intel officials say will make machine learning more energy-efficient. While quantum computing has the potential to solve problems conventional computers can't handle, the field is still nascent.

Rick And Morty Season 4 Could Come Out Late 2019 Rick And Morty Season 4 Could Come Out Late 2019 But if that's what I have to do to get another Ricklantis Mixup or Rest and Ricklaxation , then so be it. Let us know in the comment section below! " They really take their time ".

RB Guice opts for NFL Draft over staying in school RB Guice opts for NFL Draft over staying in school He missed one game and parts of others but had a breakout showing against Ole Miss with 22 carries for 276 yards and a touchdown. In sharing time with Fournette, Guice tallied 1,493 total yards and 16 touchdowns at a clip of 7.6 yards per rush back in 2016.

Christians Crackdown In China As Churches Being Destroyed Christians Crackdown In China As Churches Being Destroyed The state-run Global Times newspaper cited an unidentified local official claiming the church did not hold the necessary permits. The 50,000 strong church was originally built with 17 million Yuan (around $2.5 million) of congregation contributions.

Judge's Ruling Keeps Mulvaney in Place at CFPB Judge's Ruling Keeps Mulvaney in Place at CFPB He also wrote that there was nothing in Dodd-Frank that barred the head of OMB from also serving as acting director of the CFPB. Mulvaney has vowed to move the CFPB away from its agenda under Democratic President Barack Obama.

Merrill Lynch bars trading of bitcoin fund, futures Merrill Lynch bars trading of bitcoin fund, futures And UBS does not support or facilitate the trading of cyrptocurrencies, according to a person familiar with the situation. Advisers say clients are calling about investing in bitcoin, demand that some advisers want to satisfy.